It is a white or slightly yellow-white, crystalline powder that has a molecular weight of 248
The FDA-approved indications are leprosy and dermatitis herpetiformis
Amino acid amides of dapsone (DDS), a primary aromatic amine, have been synthesized as water-soluble, chemically stable prodrugs that target peptidase enzymes for cleavage to 2249373
The relative importance of N-hydroxylation and acetylation of dapsone to the oral clearance of dapsone (100 mg) was investigated in seven healthy volunteers
Familiarity with sulfones and dapsone is crucial because of this agent retains its niche in the clinician's therapeutic armamentarium
Little was known about the pharmacokinetics of dapsone in
Dapsone is indicated for a variety of conditions, both dermatologic and non-dermatologic
1 Substance 1
To analyze the current literature studying the efficacy of topical dapsone in the treatment of acne
Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties
Unlabeled Use: Prevention (as monotherapy) and treatment of Pneumocystis carinii pneumonia (with trimethoprim or
Pharmacodynamic modeling is based on a quantitative integration of pharmacokinetics, pharmacological systems, and (patho-) physiological processes for understanding the
Abstract
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After oral administration of 100 mg dapsone (DDS) to 25 healthy volunteers peak serum DDS concentrations between 1
Because of the theoretical increased risk for hyperbilirubinemia and kernicterus, neonatal care providers should be informed if maternal dapsone is used primaquine, dapsone
primidone will decrease the level or effect of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism
2 Plasma and salivary DDS and plasma monoacetyldapone (MADDS) and PYR were estimated simultaneously by a hitherto unpublished quantitative absorption thin layer
Dapsone (4,4′-diaminodiphenylsulfone) is an aniline derivative belonging to the group of synthetic sulfones
001) and reducing the mean percentage of all types
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1 IUPAC Name
However, this metabolite has not been detected in plasma of patients receiving dapsone
Amino acid amides of dapsone (DDS), a primary aromatic amine, have been synthesized as water-soluble, chemically stable prodrugs that target peptidase enzymes for cleavage to the parent drug in vivo
Further patients were randomized to dapsone at 200 mg or dapsone at 200 mg plus pyrimethamine at 25 mg once weekly
Concentrations of rifampicin and dapsone were estimated in timed plasma specimens
OBJECTIVE: Evaluate pharmacokinetics (PK), safety, and tolerability of 3 formulations of once-daily dapsone gel, 7
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33 μg/ml after initial tablet or proprietary liquid doses and 1
Design: A pooled analysis of data from two identically designed, randomized, double-blind, vehicle-controlled, multicenter, 12-week clinical trials